Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma
نویسندگان
چکیده
منابع مشابه
Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma
BACKGROUND Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of corticosteroids, and long acting β2-adrenergic receptor (AR) agonists (LABAs). We determined the effect of β2-AR agonists, alone or in combination with corticosteroids, on fibrocyt...
متن کاملPolymorphism of the β2-adrenoceptor and the response to long-term β2-agonist therapy in asthma
In 1990 we reported a randomized controlled trial in which the administration of regular inhaled β2-agonist therapy was associated with a deterioration in asthma control in a majority of subjects when compared to as-required β-agonist treatment [1]. There were more asthma exacerbations, reductions in the forced expiratory volume in one second (FEV1) and morning peak expiratory flow rates (PEFRs...
متن کاملCysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma
BACKGROUND The response to beta2-adrenoceptor agonists is reduced in asthmatic airways. This desensitization may be in part due to inflammatory mediators and may involve cysteinyl-leukotrienes (cysteinyl-LTs). Cysteinyl-LTs are pivotal inflammatory mediators that play important roles in the pathophysiology of asthma, allergic rhinitis, and other inflammatory conditions. We tested the hypothesis...
متن کاملInhibitory effect of Ketotifen on rat isolated uterus contraction in compare with a β2-adrenoceptor agonist and an ATP-dependent K channel activator
کتوتیفن یک بنزوسیکلوهپتاتیوفن با فعالیت های متعدد فارماکولوژیکی از جمله اثر مهاری بر روی انقباضات روده و مثانه است ولی اثرات این دارو بر روی رحم بررسی نشده است. در این تحقیق اثر کتوتیفن بر روی انقباضات ناشی از استیل کولین و کلرید پتاسیم در رحم جدا شده رات (In vitro) توسط دستگاه فیزیوگراف اندازه گیری و با اثر متاپروترنول و دیازاکسید مقایسه گردید. کتوتیفن انقباضات ناشی از کلرید پتاسیم را به صورت ...
متن کاملThe long-acting β2-adrenoceptor agonist olodaterol attenuates pulmonary inflammation
BACKGROUND AND PURPOSE β2 -adrenoceptor agonists are widely used in the management of obstructive airway diseases. Besides their bronchodilatory effect, several studies suggest inhibitory effects on various aspects of inflammation. The aim of our study was to determine the efficacy of the long-acting β2 -adrenoceptor agonist olodaterol to inhibit pulmonary inflammation and to elucidate mechanis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Respiratory Research
سال: 2017
ISSN: 1465-993X
DOI: 10.1186/s12931-017-0678-7